Accurate single cell detection in brightfield microscopy is crucial for biological research, yet data scarcity and annotation bottlenecks limit the progress of deep learning methods. We investigate the use of unconditional models to generate synthetic brightfield microscopy images and evaluate their impact on object detection performance. A U-Net based diffusion model was trained and used to create datasets with varying ratios of synthetic and real images. Experiments with YOLOv8, YOLOv9 and RT-DETR reveal that training with synthetic data can achieve improved detection accuracies (at minimal costs). A human expert survey demonstrates the high realism of generated images, with experts not capable to distinguish them from real microscopy images (accuracy 50%). Our findings suggest that diffusion-based synthetic data generation is a promising avenue for augmenting real datasets in microscopy image analysis, reducing the reliance on extensive manual annotation and potentially improving the robustness of cell detection models.

Automatic ICD coding from clinical text is a critical task in medical NLP but remains hindered by the extreme long-tail distribution of diagnostic codes. Thousands of rare and zero-shot ICD codes are severely underrepresented in datasets like MIMIC-III, leading to low macro-F1 scores. In this work, we propose a data-centric framework that generates high-quality synthetic discharge summaries to mitigate this imbalance. Our method constructs realistic multi-label code sets anchored on rare codes by leveraging real-world co-occurrence patterns, ICD descriptions, synonyms, taxonomy, and similar clinical notes. Using these structured prompts, we generate 90,000 synthetic notes covering 7,902 ICD codes, significantly expanding the training distribution. We fine-tune two state-of-the-art transformer-based models, PLM-ICD and GKI-ICD, on both the original and extended datasets. Experiments show that our approach modestly improves macro-F1 while maintaining strong micro-F1, outperforming prior SOT A. While the gain may seem marginal relative to the computational cost, our results demonstrate that carefully crafted synthetic data can enhance equity in long-tail ICD code prediction.

Machine learning has been extensively used in various applications related to eye-tracking research. Understanding eye movement is one of the most significant subsets of eye-tracking research that reveals the scanning pattern of an individual. Researchers have thoroughly analyzed eye movement data to understand various eye-tracking applications, such as attention mechanisms, navigational behavior, task understanding, etc. The outcome of traditional machine learning algorithms used for decoding tasks based on eye movement data has received a mixed reaction to Yarbus' claim that it is possible to decode the observer's task from their eye movements. In this paper, to support the hypothesis by Yarbus, we are decoding tasks categories while generating synthetic data samples using well-known Synthetic Data Generators CTGAN and its variations such as CopulaGAN and Gretel AI Synthetic Data generators on available data from an in-person user study. Our results show that augmenting more eye movement data combined with additional synthetically generated improves classification accuracy even with traditional machine learning algorithms. We see a significant improvement in task decoding accuracy from 28.1% using Random Forest to 82% using Inception Time when five times more data is added in addition to the 320 real eye movement dataset sample. Our proposed framework outperforms all the available studies on this dataset because of the use of additional synthetic datasets. We validated our claim with various algorithms and combinations of real and synthetic data to show how decoding accuracy increases with the increase in the augmentation of generated data to real data.

The development of medical chatbots in Arabic is significantly constrained by the scarcity of large-scale, high-quality annotated datasets. While prior efforts compiled a dataset of 20,000 Arabic patient-doctor interactions from social media to fine-tune large language models (LLMs), model scalability and generalization remained limited. In this study, we propose a scalable synthetic data augmentation strategy to expand the training corpus to 100,000 records. Using advanced generative AI systems ChatGPT-4o and Gemini 2.5 Pro we generated 80,000 contextually relevant and medically coherent synthetic question-answer pairs grounded in the structure of the original dataset. These synthetic samples were semantically filtered, manually validated, and integrated into the training pipeline. We fine-tuned five LLMs, including Mistral-7B and AraGPT2, and evaluated their performance using BERTScore metrics and expert-driven qualitative assessments. To further analyze the effectiveness of synthetic sources, we conducted an ablation study comparing ChatGPT-4o and Gemini-generated data independently. The results showed that ChatGPT-4o data consistently led to higher F1-scores and fewer hallucinations across all models. Overall, our findings demonstrate the viability of synthetic augmentation as a practical solution for enhancing domain-specific language models in-low resource medical NLP, paving the way for more inclusive, scalable, and accurate Arabic healthcare chatbot systems.

This paper examines the critical role of Graph Neural Networks (GNNs) in data preparation for generative artificial intelligence (GenAI) systems, with a particular focus on addressing and mitigating biases. We present a comparative analysis of three distinct methods for bias mitigation: data sparsification, feature modification, and synthetic data augmentation. Through experimental analysis using the german credit dataset, we evaluate these approaches using multiple fairness metrics, including statistical parity, equality of opportunity, and false positive rates. Our research demonstrates that while all methods improve fairness metrics compared to the original dataset, stratified sampling and synthetic data augmentation using GraphSAGE prove particularly effective in balancing demographic representation while maintaining model performance. The results provide practical insights for developing more equitable AI systems while maintaining model performance.

Harmful Algal Blooms (HABs) pose severe threats to aquatic ecosystems and public health, resulting in substantial economic losses globally. Early detection is crucial but often hindered by the scarcity of high-quality datasets necessary for training reliable machine learning (ML) models. This study investigates the use of synthetic data augmentation using Gaussian Copulas to enhance ML-based HAB detection systems. Synthetic datasets of varying sizes (100-1,000 samples) were generated using relevant environmental features$\unicode{x2015}$water temperature, salinity, and UVB radiation$\unicode{x2015}$with corrected Chlorophyll-a concentration as the target variable. Experimental results demonstrate that moderate synthetic augmentation significantly improves model performance (RMSE reduced from 0.4706 to 0.1850; $p < 0.001$). However, excessive synthetic data introduces noise and reduces predictive accuracy, emphasizing the need for a balanced approach to data augmentation. These findings highlight the potential of synthetic data to enhance HAB monitoring systems, offering a scalable and cost-effective method for early detection and mitigation of ecological and public health risks.

The generalizability of machine learning (ML) models for wearable monitoring in stroke rehabilitation is often constrained by the limited scale and heterogeneity of available data. Data augmentation addresses this challenge by adding computationally derived data to real data to enrich the variability represented in the training set. Traditional augmentation methods, such as rotation, permutation, and time-warping, have shown some benefits in improving classifier performance, but often fail to produce realistic training examples. This study employs Conditional Generative Adversarial Networks (cGANs) to create synthetic kinematic data from a publicly available dataset, closely mimicking the experimentally measured reaching movements of stroke survivors. This approach not only captures the complex temporal dynamics and common movement patterns after stroke, but also significantly enhances the training dataset. By training deep learning models on both synthetic and experimental data, we achieved a substantial enhancement in task classification accuracy: models incorporating synthetic data attained an overall accuracy of 80.2%, significantly higher than the 63.1% seen in models trained solely with real data. These improvements allow for more precise task classification, offering clinicians the potential to monitor patient progress more accurately and tailor rehabilitation interventions more effectively.

Advanced Driver Assistance Systems (ADAS) in intelligent vehicles rely on accurate driver perception within the vehicle cabin, often leveraging a combination of sensing modalities. However, these modalities operate at varying rates, posing challenges for real-time, comprehensive driver state monitoring. This paper addresses the issue of missing data due to sensor frame rate mismatches, introducing a generative model approach to create synthetic yet realistic thermal imagery. We propose using conditional generative adversarial networks (cGANs), specifically comparing the pix2pix and CycleGAN architectures. Experimental results demonstrate that pix2pix outperforms CycleGAN, and utilizing multi-view input styles, especially stacked views, enhances the accuracy of thermal image generation. Moreover, the study evaluates the model's generalizability across different subjects, revealing the importance of individualized training for optimal performance. The findings suggest the potential of generative models in addressing missing frames, advancing driver state monitoring for intelligent vehicles, and underscoring the need for continued research in model generalization and customization.

Insufficiency of training data is a persistent issue in medical image analysis, especially for task-based functional magnetic resonance images (fMRI) with spatio-temporal imaging data acquired using specific cognitive tasks. In this paper, we propose an approach for generating synthetic fMRI sequences that can then be used to create augmented training datasets in downstream learning tasks. To synthesize high-resolution task-specific fMRI, we adapt the $\alpha$-GAN structure, leveraging advantages of both GAN and variational autoencoder models, and propose different alternatives in aggregating temporal information. The synthetic images are evaluated from multiple perspectives including visualizations and an autism spectrum disorder (ASD) classification task. The results show that the synthetic task-based fMRI can provide effective data augmentation in learning the ASD classification task.

We introduce Train/Test-Time Adaptation with Retrieval (${\rm T^3AR}$), a method to adapt models both at train and test time by means of a retrieval module and a searchable pool of external samples. Before inference, ${\rm T^3AR}$ adapts a given model to the downstream task using refined pseudo-labels and a self-supervised contrastive objective function whose noise distribution leverages retrieved real samples to improve feature adaptation on the target data manifold. The retrieval of real images is key to ${\rm T^3AR}$ since it does not rely solely on synthetic data augmentations to compensate for the lack of adaptation data, as typically done by other adaptation algorithms. Furthermore, thanks to the retrieval module, our method gives the user or service provider the possibility to improve model adaptation on the downstream task by incorporating further relevant data or to fully remove samples that may no longer be available due to changes in user preference after deployment. First, we show that ${\rm T^3AR}$ can be used at training time to improve downstream fine-grained classification over standard fine-tuning baselines, and the fewer the adaptation data the higher the relative improvement (up to 13%). Second, we apply ${\rm T^3AR}$ for test-time adaptation and show that exploiting a pool of external images at test-time leads to more robust representations over existing methods on DomainNet-126 and VISDA-C, especially when few adaptation data are available (up to 8%).